Generally, we start domperidone at 20 mg (two 10 mg tablets) 4 times a day. If taking domperidone 4 times a day is inconvenient, 30 mg (three 10-mg tablets) 3 times a day is fine. Printouts from the pharmacy often suggest taking domperidone 30 minutes before eating, but that is because of its use for digestive intolerance. You can take the domperidone about every 6 hours, when it is convenient (there is no need to wake up to keep to a 6-hour schedule - it does not make any difference). Most mothers take the domperidone for 3 to 8 weeks. Mothers who are nursing adopted babies may have to take the drug much longer.

After starting domperidone, it may take 3 or 4 days before you notice any effect, though sometimes mothers notice an effect within 24 hours. It appears to take 2 to 3 weeks to get a maximum effect, but some mothers have noted effects only after 4 or more weeks. It is reasonable to give domperidone a trial of at least 4 weeks before saying it doesn’t work.