The use of intravenous immunoglobulin in sine causa or alloimmune recurrent spontaneous abortion (RSA).

Panminerva Med 2000 Sep;42(3):193-5 (ISSN: 0031-0808) 
Patriarca A; Piccioni V; Gigante V; Benedetto C 
Department of Obstetrics and Gynecology, Chair C, University of Turin, Italy.


Recurrent spontaneous abortion (RSA) has an incidence of 0.5%-1%. It is thought that immune reaction disorders in the mother may evolve in unexplained RSA, which has a higher incidence in women over 40 years old.


Twenty-three patients with recurrent spontaneous abortion of unknown origin and two autoimmune cases were treated with intravenous specific immunoglobulins at the 5th-6th week of pregnancy and fifteen days later.


After treatment, nineteen patients brought their pregnancy to term, five aborted, one is pregnant at present.


The use of immunoglobulins seems to be efficacious in recurrent spontaneous abortion of unknown origin. Our results support the theory that this treatment is able to passively transfer the sparking off factor that allows the pregnancy to evolve.