Oh...I had no idea...I just started as soon as I received my pills. When you say day 5 do you mean day 5 of my cycle?? I am confused ? Also I do have breast changes not dramatic like one whole cup size up, but I do feel my breast are more dense and the achy feeling is there.. no pain just a slight soreness, does that get more dramatic by day 10 or does that pretty much level off by this point? BTW I am 46 perhaps that has an impact on the effect of the hormones on my breasts?? not as effective? Since my hormones are already a little out of order!! in comparison to a 26-36 year old?? Thanks for the reply..